SilkAir, the regional wing of Singapore Airlines flies directly from Singapore to Manado, four times per week. The other international connection is from Davao to Manado. There are Sriwijaya AirGaruda Airways, Merpati Airlines, Lion Air, and Batavia Air are domestic airllines flying from Jakarta to Manado . Sriwijaya Air flight from Jakarta to Manado via Surabaya. There is also daily flight from Bali to Manado via Makassar by Garuda Airways & Lion Air.

Manado also can be reached by sea via International Port of Bitung with PELNI and it takes 1,5 hours by car from Bitung City to Manado.